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br A brief introduction to
2020-04-02
A brief introduction to DUBs The reversal of ubiquitin conjugation of targeted proteins relies on deubiquitinating Fosmidomycin sodium salt synthesis (DUBs), which catalytically cleave single Ub or poly-ubiquitin chains from proteins. The human genome encodes approximately 100 potential DUBs whi
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Interest in the PGE EP pathway is
2020-04-02
Interest in the PGE2/EP4 pathway is increasing given its diverse capability of regulating central nervous system activity [13]. EP4 has a protective function by reducing cerebral injury and improving functional outcome after stroke [14], and in suppressing EZLink NHS-Biotin Kit inflammation [15]. T
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Oltipraz br Conflict of Interest br
2020-04-02
Conflict of Interest Acknowledgements Marques F. was supported by the Foundation for Science and Technology (FCT), Portugal, Grant UMINHO/BI/35/2012. This work was supported by FCT by the Project PTDC/AGR-AAM/70418/2006. Introduction β-methylamino-l-alanine (BMAA) exposure has long been as
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Thus RhoA mediated inhibition of DGK is a
2020-04-02
Thus RhoA-mediated inhibition of DGKθ is a well-characterized pathway, conserved from C. elegans to mammalian tissues, which enables G-protein coupled receptors to regulate the extent and kinetics of DAG-mediated signaling by fine tuning DGK enzymatic activity. Acknowledgments Introduction Ce
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br Results and Discussion br Materials and
2020-04-01
Results and Discussion Materials and Methods Acknowledgements Introduction Among the solid tumors, Prostate cancer (PCa) has been one of the most frequently diagnosed malignancy in men and the second male\'s cancer related deaths in the developed countries [1]. In China, the incidence an
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Contrary to genetic aberrations epigenetic methylation marke
2020-04-01
Contrary to genetic aberrations epigenetic methylation markers with broad coverage of OvCa subtypes were detected in primary tumors [21]. Ibanez de Caceres et al. [22] identified hypermethylation of BRCA1, APC, p16, p14, DAPK or RASSF1A in 50 of 50 primary tumors. Moreover the methylation pattern wa
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Indeed some cancers may even be defined by dysregulated cycl
2020-04-01
Indeed, some cancers may even be defined by dysregulated cyclin and thus CDK activity: mantle cell lymphoma, an uncommon lymphoma of mature B cells, is defined by the presence of overexpressed cyclin D1, usually as a result of a translocation between chromosomes 11 and 14 with the net result that cy
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In summary these findings show that
2020-04-01
In summary, these findings show that the knockdown of tra2 in the Drosophila fat body results in an increased triglyceride phenotype, which could be explained in part by altered splicing of the gene coding for the lipid breakdown enzyme, CPT1. These findings are consistent with previous studies anal
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br Experimental br Declaration of interest br Introduction b
2020-04-01
Experimental Declaration of interest Introduction Material and methods Results and discussion Conclusion By screening the NMR serine protease inhibitors library an initial hit was found for an inhibitor of the PPI between the α-β subunits of CK2 with an IC50 of 900 μM. This compou
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br Effects of estradiol outside the
2020-04-01
Effects of estradiol outside the nucleus are often mediated by classical estrogen receptors Today, it is widely accepted that steroid hormones can signal in ways that do not rely on receptors acting in the nucleus, including activation of receptors localized to the cellular membrane. Rapid effect
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Furthermore certain components in the
2020-04-01
Furthermore, certain components in the Melanocyte Growth Medium seem to influence the response to UV radiation [17]: UV-induced effects on tyrosinase activity were less distinct in melanocytes cultured with phorbol 12-myristate 13-acetate [18], which was also an ingredient in our Melanocyte Growth M
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Because most fusion detection methods were developed to anal
2020-04-01
Because most fusion detection methods were developed to analyze paired-end reads (and especially Illumina data), they are not suitable for identifying fusion junction-spanning reads in single-end Ion Torrent libraries. Therefore, we developed the FusionDetect algorithm (implemented in the ChildDecod
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br Molecular genetics Based on the genetic mutations associa
2020-04-01
Molecular genetics Based on the genetic mutations associated with their development, sarcomas are subdivided into two distinct classes. One class is composed of tumors bearing complex karyotypic abnormalities with no particular pattern. The second class, which includes Ewing sarcoma, encompasses
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Carbazole could be recrystallised from ethyl acetate to
2020-04-01
Carbazole could be recrystallised from ethyl acetate to provide bright red crystals suitable for single crystal X-ray diffraction (see ). The first crop showed had crystallised preferentially as the ()-isomer (A). Examining the single crystal X-ray data of it was interesting to find that the N2C1
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The aniline R group was extensively explored and a large
2020-04-01
The aniline R2 group was extensively explored and a large variety of substitution was tolerated at several positions on the aryl ring (). Notably, substitution at the 3-position often gave increased potency. Increasing lipophilic bulk at this position gave increasing potency within an ether series (
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