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It is currently believed that acute morphine administration
2020-01-02
It is currently believed that acute morphine administration can impair learning and memory (Friswell et al., 2008). Chronic morphine treatment can also impair access to and retention of spatial memory (Spain and Newsom, 1991, Zheng et al., 2002). Using the Morris water maze experiment, we have previ
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In anticipation of an approach based on modification
2020-01-02
In anticipation of an approach based on modification of the cyclohexylacetic PTP Inhibitor IV sale subunit of 1 as a means of improving permeability, a set of analogs were prepared to map out the optimum display of the acidic functionality. Homologated acids 25 and 26 were found to be equipotent to
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In neurodegenerative disorders neurons are excited by
2020-01-02
In neurodegenerative disorders neurons are excited by enormous ionic flow which induces mitochondrial dysfunction and apoptosis. Glutamate as the main excitatory neurotransmitter, is released excessively in these diseases. Glutamate acts through N-methyl-d-aspartate (NMDA) receptor and α-amino-3-hyd
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The DDR gene located on chromosome
2020-01-02
The DDR1 gene, located on chromosome region 6p21.33, encodes a transmembrane tyrosine kinase receptor involved in melanocyte anchoring through binding to collagen IV (Silva de Castro et al., 2010). So far, only three studies have been conducted on the association between DDR1 polymorphism and the ri
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The present study provides the first evidence that the human
2020-01-02
The present study provides the first evidence that the human uroepithelial Scrambled 10Panx sale in vitro respond directly, within 48h, to this carcinogen by promoting extensive vacuolation and DAPK expression. By using the TEM, ICC and Western blotting, we found that the arsenite-induced vacuoles w
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In the present study we
2020-01-02
In the present study, we combined activity-based protein profiling, biochemical and genetic approaches to identify the PLCPs involved in the sphingolipid pathway leading to plant PCD. By using Arabidopsis 490 3 synthesis and leaves, we demonstrate that this sub-class of plant proteases is activated
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Most data regarding fish CXCR
2020-01-02
Most data regarding fish CXCR4 functions have accumulated from work in zebrafish where a range of genetic tools and imaging technologies have been developed. As mentioned above, in teleost fish the two CXCR4s (CXCR4a and 4b) are assumed to interact with two ligands (CXCL12a and 12b) and this differe
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br Conflicts of interest br Acknowledgments
2020-01-02
Conflicts of interest Acknowledgments This research was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (NRF-2015R1A2A2A01004593). Introduction Resistance to Inhibitors of Cholinest
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E ligases provide substrate recognition specificity Ubiquiti
2019-12-31
E3 ligases provide substrate recognition specificity Ubiquitination Physcion and substrate specificity in mammals is achieved by the existence of over six-hundred E3-ubiquitin ligases that catalyze the final step of ubiquitination, compared with only one E1 and very few E2 enzymes known till date [
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Several functions of FAT have
2019-12-31
Several functions of FAT10 have been suggested. It has been shown that FAT10 binds noncovalently to the mitotic spindle checkpoint protein MAD2 and that this binding might cause chromosome instability in the cancer berbamine overexpressing FAT10 (Liu et al., 1999, Ren et al., 2006). In other studies
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br Materials and methods br Results br Discussion The
2019-12-31
Materials and methods Results Discussion The incretin hormones potently stimulate insulin secretion, and it is generally assumed that this is mediated by an endocrine mechanism such that GIP and GLP-1 through the circulation reach the islet beta Nicotine australia to stimulate their secret
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The Rev protein is a
2019-12-31
The Rev1 protein is a crucial regulator of TLS activity because of its structural function [10]; therefore, we focused on Rev1 to investigate how Dot1/Rad53 function impinges on TLS-dependent mutagenic bypass of MMS-induced lesions. In particular, we examined Rev1 localization to chromatin by immuno
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Expression of MGMT in human cells
2019-12-31
Expression of MGMT in human Teicoplanin can be switched off by enzymatic methylation of a cytosine residue in the MGMT promoter sequence. In this regard, both MGMT and the mismatch repair function MLH1 belong to a subset of DNA repair genes that are subjected to epigenetic control. In consequence, a
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The most important cytotoxic lesion formed by
2019-12-31
The most important cytotoxic lesion formed by the nitrogen mustards is generally considered to be the DNA–DNA interstrand cross-link 12, 13. DNA–DNA interstrand cross-links are thought to exert their cytotoxic effects by inhibiting DNA duplex strand separation, progression of the OSI-930 fork and D
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mdm2 inhibitor This paper proposes an acceptance process and
2019-12-31
This paper proposes an acceptance process and evaluation criteria, specialized for the dedication of indirect COTS SW as well as direct ones. (Step 1) It first recognizes an indirect COTS SW as a target of dedication, unlike EPRI NP-5652/TR-106439. (Step 2) It then determines the safety category of
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