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br Conclusion br Conflict of interest br Acknowledgments
2023-04-14
Conclusion Conflict of interest Acknowledgments We thank Nancy Kerkvliet for helpful advice. The research in the lab of CE and THS is supported by the Deutsche Forschungsgemeinschaft (grants ES103/7-1 and 9-1, HA7346/2-1). We apologize to all authors whose work could not be cited due to lim
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Nrf br AhR br Nrf
2023-04-14
Nrf2 AhR Nrf2 and AhR: friends or foes for energetic metabolism? Perspectives in carcinogenesis upon xenobiotic exposure Acknowledgements Introduction Integration of endogenous and exogenous signals via appropriate receptors is at the core of biological differentiation and adaptive r
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Similar to V the temporal neocortex of mammals including
2023-04-14
Similar to V1, the temporal neocortex of mammals, including the primary auditory cortex (A1), is densely innervated by 5-HT fibers originating mainly in the dorsal raphe nucleus (Campbell et al., 1987, Harding and Paxinos, 2004, Törk, 1990), and the major btk inhibitor of 5-HTRs are expressed throu
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Active SI behavior was dose dependently affected by PACAP
2023-04-14
Active SI behavior was dose-dependently affected by PACAP treatment (F3,25 = 14.42, p Novobiocin Sodium 1 week later (F3,20 = 8.93, p hypothesis that PACAP causes disruptions in posterror adjustments that are similar to disruptions seen in humans with depression.
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Various cardiovascular diseases show a high occurrence of au
2023-04-14
Various cardiovascular diseases show a high occurrence of autophagosomes. Whereas basal autophagy is required for the proper functioning of cardiomyocytes [82], the deletion of Atg5 gene in myocardium shows a high risk of cardiomyopathy [83]. Hamacher et al. observed that an upregulation of Bnip3, a
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Another important question concerns the mechanism by which a
2023-04-14
Another important question concerns the mechanism by which a polyubiquitinated substrate is released from the Cdc48 complex and passed on to downstream components, such as the proteasome. There are at least three proposed models. In the first, a ubiquitinated substrate is transferred by ubiquitin-bi
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br Colorectal carcinoma The growth rate of
2023-04-14
Colorectal carcinoma The growth rate of murine colon adenocarcinoma tumors decreased upon inhibition of 5-LOX, an enzyme that harbors counteracting properties to 15-LOX [28]. It is not clear whether 15-LOX was associated with this phenomenon, but its expression is induced in the colon carcinoma c
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Hesperadin mg br Activity and expression of aromatase in the
2023-04-14
Activity and expression of aromatase in the hippocampus The brain, like the adrenals, gonads and the placenta, is a steroidogenic organ. This paradigm emerged from studies carried out as early as the 1980s by Baulieu and co-workers; these studies showed that steroids such as pregnenolone and dehy
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ML347 sale Expression subcellular localization transcription
2023-04-14
Expression, subcellular localization, transcriptional activity and protein stability of Foxo are regulated by proteins such as STAT3, PKB, JNK and AMPK (Sun et al., 2017; Zhang et al., 2011). STAT3 is a member of the signal transducer and activator of transcription (STAT) protein family that plays c
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In our sequential model for tau and A deposition we
2023-04-13
In our sequential model for tau and Aβ deposition, we included the tau deposition in the medial temporal Telatinib in the absence of Aβ deposition, which is a pathological definition of primary age-related tauopathy (PART). Although the tau pathologies in PART and AD are almost identical in their ne
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Previous studies have demonstrated that
2023-04-13
Previous studies have demonstrated that synaptic AMPARs can differ greatly in their mobility; some rapidly and constitutively AL 8810 in and out of the synaptic membrane, while others remain somewhat stable in the synaptic membrane (Luscher et al., 1999, Luthi et al., 1999). We find that mGluR- and
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According to average serum fat content of g L Phillips
2023-04-12
According to average serum fat content of 6.9 g/L (Phillips et al., 1989) and serum dioxin level from individuals exposed to dioxins as the result of accidents in Seveso (Needham et al., 1997), Taiwan (Guo et al., 2004) and Vietnam (The Tai et al., 2011) the median serum concentration of TCDD would
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br Conclusions The present data suggest that homeostatic bal
2023-04-12
Conclusions The present data suggest that homeostatic balance of the cortical/hippocampal adenosinergic tone is necessary for normal working memory function and any deviation appears to impair performance – either as a consequence of A2AR under-activation when adenosine levels are reduced or due
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br Occurrence of Inosine in
2023-04-12
Occurrence of Inosine in RNA Inosine is widespread among various types of RNAs including transfer RNA (tRNA), ribosomal RNA (rRNA), messenger RNA (mRNA), long noncoding RNA (lncRNA), and microRNA (miRNA). Within these RNAs, inosine can appear in different locations as well. Table 1 lists examples
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To better understand the pathophysiology of ASDs we
2023-04-12
To better understand the pathophysiology of ASDs, we would need comprehensive information on a) the functions of ASD-associated proteins in the brain, b) how mutations affect the expression level and function of these proteins, c) how mutations affect their function in neurons, and d) how changed ne
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