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Analogous to all GPCRs the GLP
2022-09-01
Analogous to all GPCRs, the GLP-1R transduces signals from the outside of the cell to the inside by allosterically converting a ligand-binding event to activation of intracellular effectors. The GLP-1R couples to several intracellular effectors and this pleiotropic coupling is physiologically releva
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br Acknowledgments br Introduction When human red blood cell
2022-09-01
Acknowledgments Introduction When human red blood cell (hRBC) membranes are depolarized, either as intact mth1 pathway suspended in depolarizing (low Cl−) Ringers or under voltage clamp conditions using excised inside-out patches, they respond by opening a nonselective voltage-dependent catio
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Experiments show that CSD propagation can be
2022-09-01
Experiments show that CSD propagation can be slowed or interrupted by pre-existing lesions or areas of high astrocytic density (Chen et al., 2006), and reduced expression of astrocytic gap junctions significantly increases the size of ischemic infarcts (Nakase et al., 2003). By decreasing the gap ju
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br Materials and methods br Results and discussion
2022-09-01
Materials and methods Results and discussion Conclusions Notes Declaration of interest statement Acknowledgment This work was supported by the National Natural Science Foundation of China (No. 21775132, 21505112), Scientific Research Foundation of Hunan Provincial Education Departm
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Prion diseases are transmissible and result in fatal neurode
2022-09-01
Prion diseases are transmissible and result in fatal neurodegenerative disorders, which, similar to AD, also involve the infiltration and activation of mononuclear phagocytes in Eptifibatide lesions (reviewed in [61]). A 21 amino-acid fragment of the aberrant human prion protein, Prp106–126, can fo
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In this study it was
2022-09-01
In this study it was demonstrated that also in mice chronically exposed to CS, lung inflammation persists after SC and is associated with a progressive alveolar loss and remodeling of respiratory tract, characterized by the onset of bronchial and bronchiolar GCM and peribronchiolar fibrosis. Persist
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Our previous study had shown that
2022-09-01
Our previous study had shown that silencing FFAR1 expression weakened the action of PIO in increasing insulin secretion in lipotoxic β Apocynin [6]. Resent research found that PIO promoted insulin secretion by upregulating FFAR1 [17]. Therefore, we presumed that FFAR1 may be involved in the anti-lip
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1670 sale When taken together data suggest CRF
2022-09-01
When taken together, data suggest CRF plays a central role in linking the HPA axis, the eCB system, and the amygdala with anxiety (Hill et al., 2009, 2010a; Hillard et al., 2011). In elaborate studies in mice, Gray and colleagues (Gray et al., 2015) showed stress-associated increase in CRF concentra
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br Conclusion We have demonstrated that ETB receptors negati
2022-09-01
Conclusion We have demonstrated that ETB receptors negatively regulate the expression of AT1 receptors in renal proximal tubule Ac-IETD-AFC receptor from WKY rats but not in SHRs. Short-term activation of the ETB receptor increases AT1 receptor phosphorylation in WKY cells but decreases it in SH
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microRNAs miRNAs of approximately nucleotides
2022-08-31
microRNAs (miRNAs) of approximately 22 nucleotides play vital roles in cancer development and progression by regulating translational repression or decay of target messenger RNAs (mRNAs) through their binding to the 3′-untranslated regions (3′-UTRs) of target mRNAs with imprecise or precise compleme
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CD CD belong to the costimulatory
2022-08-31
CD80/CD86 belong to the costimulatory adhesion molecule family, which can activate T LY364947 by the costimulatory pathway and have been used as indicators of DC maturation in numerous studies. In addition, MHC-II, as the principal component of antigen presentation, was significantly elevated after
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Several plant derived molecules such as resveratrol curcumin
2022-08-31
Several plant-derived molecules such as resveratrol, curcumin, zerumbone, and physalin B have been reported as modulators of Hh/Gli signaling pathway (Hosoya et al., 2008, Mohapatra et al., 2015). Our previous studies have demonstrated that a sesquiterpene lactone and diarylheptanoids from Siegesbec
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To solve the atomic structures of several individual domains
2022-08-31
To solve the atomic structures of several individual domains and a complete molecular architecture of sGC, tangible experimental research work has been done which resulted in a cryo-electron density map of R. norvegicus. However, the full structure of the human sGC remains to be determined. In the p
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br Introduction Atherosclerosis is a chronic inflammatory di
2022-08-31
Introduction Atherosclerosis is a chronic inflammatory disease characterized by lipid and leukocyte accumulation within the arterial wall. Homocysteine (Hcy) is a thiol-containing amino BAMB-4 sale derivative derived from the metabolism of dietary methionine. Epidemiological studies have shown t
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br Introduction Atherosclerosis is a chronic inflammatory di
2022-08-31
Introduction Atherosclerosis is a chronic inflammatory disease characterized by lipid and leukocyte accumulation within the arterial wall. Homocysteine (Hcy) is a thiol-containing amino BAMB-4 sale derivative derived from the metabolism of dietary methionine. Epidemiological studies have shown t
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