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br Dysregulation of glutamate transporter
2021-12-01
Dysregulation of glutamate transporter expression and function Aberrant glutamate transporter function and expression are associated with various neurological disorders. Therefore, understanding the underlying mechanisms of EAAT1/2 expression may provide therapeutic targets for treating neurologi
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Glucose uptake a critical metabolic control point in
2021-12-01
Glucose uptake, a critical metabolic control point in glycolysis, is mediated by the GLUT (SLC2) family of integral membrane transporters (Mueckler and Thorens, 2013). GLUT1 (SLC2A1), one of the most well-studied members of the SLC2 family, exhibits a wide tissue distribution; cell surface expressio
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The expression of GLUT receptors throughout the body could b
2021-12-01
The expression of GLUT receptors throughout the body could be considered a potential source for off-target effects even for engineered glucose-conjugated nanomedicines, as there are at least 12 types of GLUT transporters in the body, including GLUT1 in erythrocytes and the blood-brain barrier, as we
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Interestingly the subcellular localization of FBPase in
2021-12-01
Interestingly, the subcellular localization of FBPase in hepatocytes and proximal tubule rgd peptide reveals that FBPase is also able to translocate to the nucleus in these cell types. The nuclear localization of muscle-FBPase was recently reported [35]. This data corroborate our results on the abil
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ADAM has two alternative splicing forms a membrane anchored
2021-12-01
ADAM12 has two alternative splicing forms, a membrane-anchored long form (ADAM12-L) and a secreted short form (ADAM12-S). Both the long and short forms have metalloproteinase, disintegrin, cysteine-rich, and epidermal growth factor-like domains and can shed pro-heparin binding-epidermal growth facto
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There are limited studies on antibody responses against
2021-12-01
There are limited studies on antibody responses against HIV-1 integrase antigen. According to previous studies, almost 5 percent of individuals infected with HIV never raise anti-integrase many years (Rikhtegaran Tehrani et al., 2015; Chang et al., 1985). If this rate is identical in individuals in
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Newly identified evidence has put immune checkpoint inhibito
2021-12-01
Newly identified evidence has put immune checkpoint inhibitors into the spotlight. However, even though they have been reported to achieve optimistic outcomes [67], there is still a provocative question about their limitations [68]. The solid evidence above has provided us with translational values
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The central region of Azalanstat can be substituted with con
2021-12-01
The central region of Azalanstat can be substituted with connecting alkyl chains of different nature and length. Interesting results were given by compounds with a four or five Dihydrodaidzein synthesis chain, incorporating heteroatoms, such as oxygen (Fig. 2, compound 4) or sulfur, and different f
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Under increased drug pressure more protease
2021-12-01
Under increased drug pressure, more protease variants with more than one substitution will likely become clinically relevant. The accumulation of additional substitutions can allow RAS variants to emerge that alone are not viable, but in combination can rescue the viral fitness. We previously demons
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The stress of accelerated lactate production in cancer
2021-12-01
The stress of accelerated lactate production in cancer Fmoc-Ile-Wang resin is moderated by the overexpression of lactate transporters – symporters for lactate anions and protons called monocarboxylate transporters (MCTs) – that are capable of bidirectional transport depending on the environmental an
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The ketone body receptor HCA is most
2021-12-01
The ketone body receptor HCA2 is most likely not active under normal conditions, since local levels and plasma levels of ketone bodies such as β-HB are too low to activate the receptor. However, overnight fasting or prolonged starvation results in plasma levels of the ketone body in the millimolar r
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Finally LC ESI MS MS was
2021-12-01
Finally, LC-ESI-MS/MS was applied to explore the effects of increased fT4 levels 4 and 8 weeks after induced thyrotoxicosis and have revealed an upregulation of proteins involved in blood coagulation, thus providing a clear association [126]. Conclusions Introduction Diabetes mellitus (DM) ha
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Depressed survival rate body weight
2021-12-01
Depressed survival rate, body weight, and colon length along with elevated clinical score comprise the essential characteristics of IBD (Hung et al., 2014; Shen et al., 2011; Sun et al., 2010). In the present study, we found that SB improved the survival rate, body weight, and colon length and decre
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MK-8745 After initial validation of the ability of Ad Cre vi
2021-12-01
After initial validation of the ability of Ad5-Cre virus to express Cre recombinase protein in glial cells in vitro and in vivo, we employed this virus to induce site-specific deletion of our target GlyT1 in the thalamus, through injection of the cKO GlyT1 mice. This transgenic line was constructed
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On the contrary the benzhydrol
2021-11-30
On the contrary, the benzhydrol series showed modest activity with EC of two digit micromole. The bulkiness of the Sennoside C tail may be the reason for the low activity. Interestingly, introduction of H-bonding groups, such as OMe in and CF in , slightly improved the activity compared to the uns
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