Archives
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Next we examined the SAR
2020-07-30
Next, we examined the SAR of the amide linker moiety of 15-19 and 15-20 (Table 3). An N-methylamide 15-34, which was devoid of the hydrogen bond donor (NH) showed a 15-fold reduction in the binding affinity (15-34: IC50=210nM), suggesting that the hydrogen bond donor (NH) is likely to contribute to
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Atomic structures of mammalian and fungal CRM alone and in
2020-07-30
Atomic structures of mammalian and fungal CRM1, alone and in complex with different binding partners, have revealed that CRM1 undergoes multiple conformational changes as it shuttles between the nucleus, where cooperative assembly of the CRM1/Ran/cargo complex occurs, and the cytosol, where the comp
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Nicotine dependence drives the habit of smoking which causes
2020-07-30
Nicotine dependence drives the habit of smoking, which causes a heavy load of disease and death, as smoking is one of the largest contributors to preventable morbidity and mortality (GBD 2015 Risk Factors Collaborators, 2016; World Health Organization(WHO), 2017). Inhaled nicotine reaches the brain,
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It was found that qCPA all approaches significantly improves
2020-07-30
It was found that qCPA (all approaches) significantly improves the prediction of binary VLE and the correlation of LLE between CO2+n-alkane mixtures. A significantly smaller interaction parameter is needed to correlate the experimental data with qCPA compared to the CPA approaches. When it comes to
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In N crassa a point mutation
2020-07-30
In N. crassa, a point mutation conferring a single amino beta-Nicotinamide mononucleotide mutation (His to Arg substitution at amino acid 351 within catalytic domain VII of the kinase) of COT-1 protein resulted in the formation of a temperature sensitive strain, exhibiting severe morphological defe
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The Pacific cup oyster genus
2020-07-30
The Pacific cup oyster, genus Saccostrea, has been used in Australia and Asia as a sentinel bivalve for pollution monitoring, particularly of metals (Barua et al., 2011, Thompson et al., 2011, Thompson et al., 2012a, Thompson et al., 2012b, Andrew-Priestley et al., 2012, Taylor et al., 2013, Taylor
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Postranslation protein modification via addition of the high
2020-07-29
Postranslation protein modification via addition of the highly conserved ubiquitin to substrate proteins by E1, E2 and E3 enzymes occurs frequently in eukaryotic Conessine (Popovic et al., 2014, van Wijk and Timmers, 2010). Poly-ubiquitination usually targets the substrate proteins for destruction
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We have shown that the glycation
2020-07-29
We have shown that the glycation of collagen hinders collagen-DDR2 binding. McCarthy et al. previously showed reduced binding of rat osteosarcoma-derived cells (UMR106) to glycated collagen. The authors speculated that glycation of collagen attenuates collagen binding to collagen-specific integrins
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In reviewing the literature it is apparent that three
2020-07-29
In reviewing the literature, it is apparent that three major methodological approaches are used to evaluate the behavioral effects induced by targeted SZL P1-41 synthesis alterations. These methods include knockout procedures, antisense oligonucleotide strategies, and administration of specific CRF
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Thus the genetic tools used in these studies come with
2020-07-29
Thus, the genetic tools used in these studies come with certain limitations too, and thus is it too early to rewrite the “Guide to immunometabolism for immunologists” (O’Neill et al., 2016). Clearly more detailed comparative studies will be needed to reconcile some of the contradictory findings in t
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Recently a series of our studies
2020-07-28
Recently, a series of our studies confirmed that LMP1 contributes to the radioresistance of NPC. LMP1 might promote radioresistance by regulating tumor angiogenesis through the JNKs/HIF-1 pathway or glycolysis through the up-regulation of hexokinase 2 (HK2), a rate-limiting enzyme of glycolysis, or
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br Acknowledgments This work was supported by
2020-07-28
Acknowledgments This work was supported by FAPESP, São Paulo, Brazil, (Grants # 2014/15982-6 and 2013/21075-9); CNPq and CAPES (Brasília, DF, Brazil). We thank Dr. Julian Sale (Medical Research Council Laboratory of Molecular Biology, Cambridge, UK) for critical reading of this review. Introdu
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The reduced DNA stability at RH
2020-07-28
The reduced DNA stability at 100% RH confirms previous results for incubates at these conditions, although in the present study amplifiable DNA still survived for months. The crucial point appears to be the onset of microbial growth, which happened at room temperature and at 35 °C. In the biological
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Hence the present study intended to investigate whether DNA
2020-07-28
Hence, the present study intended to investigate whether DNA promoter hypermethylation can further amplify the stratifying effectiveness in this clinically debating patient population. Four candidate iepd were selected for validation, of which we mainly focused on RASSF1A and DAPK due to their pote
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A series of monocarboxylated chalcones e g compounds and Fig
2020-07-28
A series of monocarboxylated chalcones (e.g. compounds 7 and 8, Fig. 2A) was previously identified as good CysLT1 antagonists [20], and none of them exhibited CysLT2 antagonistic activities (Supplementary Table S1). This study was consistent with reported result that CysLT2 SJ 172550 was not sensiti