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Herein we describe the design and optimization
2021-10-21
Herein, we describe the design and optimization of fused-ring phenyl propanoic acids as novel GPR40 agonists, leading to the discovery of compound 40a which exhibits excellent pharmacokinetic properties, improved hepatobiliary transporter inhibition, and significant glucose-lowering efficacy during
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Several bacterial functional pathways were
2021-10-21
Several bacterial functional pathways were observed after DON administration, of which signal transduction, metabolism and genetic information processing displayed the highest levels of enrichment. Importantly, these three pathways were reported to be closely associated with DON's toxicity. Many evi
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br Materials and methods br Results br
2021-10-21
Materials and methods Results Discussion Genetic analyses conducted here were based on specific features of PhyChem indexes for nt dimers extracted to generate a numerical sequence representation, which was used to build models for distinguishing HVR1 variants between CIP and MIP. This data
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Beckman Coulter s DxN VERIS Molecular Diagnostics System DxN
2021-10-21
Beckman Coulter’s DxN VERIS Molecular Diagnostics System (DxN VERIS System) is a fully automated system for the quantitative analysis of molecular targets, integrating sample introduction, nucleic LY 294002 extraction, reaction set-up, real-time PCR amplification and detection using TaqMan® chemist
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Of what interest is the link
2021-10-20
Of what interest is the link between GSNOR and NO in the plant response to Fe deficiency? On the one hand, NO acts as an important signal to help plants accommodate Fe deficiencies; on the other hand, surplus NO is indeed a harmful RNS that induces severe S-nitrosylation-related damage at a higher s
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Finally LC ESI MS MS was applied to explore
2021-10-20
Finally, LC-ESI-MS/MS was applied to explore the effects of increased fT4 levels 4 and 8 weeks after induced thyrotoxicosis and have revealed an upregulation of proteins involved in blood coagulation, thus providing a clear association [126]. Conclusions Introduction Diabetes mellitus (DM) ha
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Ciclopirox br Next we explored the SAR
2021-10-20
Next, we explored the SAR around the aryl ring attached to the pyrrole nitrogen in the presence of the 3-CF and the 2,6-difluorophenylpropionic Ciclopirox sidechain (). The EC value of the unsubstituted phenyl was about 100 nM. The 4-methyl was 2-fold more potent, however ethyl and bromo did
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In both families GPR A mRNA in
2021-10-20
In both families, GPR109A mRNA in kidney fat was positively correlated with NEFA as a tendency. A positive correlation between this fat depot and insulin was observed in lean-type cows. In fat-type cows, mesenteric GPR109A mRNA correlated positively with insulin and negatively with urea on a moderat
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The differential tissue and ligand dependent signaling descr
2021-10-20
The differential tissue- and ligand-dependent signaling described here has important implications for the therapeutic potential of synthetic GPR109A agonists for the treatment of atherosclerosis. The failure of MK-0354, a biased, partial GPR109A agonist, to activate signaling pathways upstream of va
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To search for potential variants of
2021-10-20
To search for potential variants of SLA-DOB and CD4 associated with different (percentage) levels of the five (T-lymphocyte subsets, total antibody IgG, interferon alpha (IFN-α), Toll like receptor 3 (TLR3), interleukin 6 (IL-6) in serum and porcine reproductive and respiratory syndrome virus (PRRSV
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br Materials and methods br
2021-10-20
Materials and methods Results Discussion To fulfill its role in tissue homeostasis, repair and immunoregulation, MSCs must be able to (i) renew themselves by cell division and proliferation, (ii) migrate to its target end-site in response to chemotaxis signals and (iii) undergo appropriate
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Telotristat In conclusion this is the first study
2021-10-20
In conclusion, this is the first study performed in acute limbic seizure models that shows the ability of DAG to dose-dependently attenuate pilocarpine-induced seizures, albeit at a higher concentration as ghrelin (Portelli et al., 2012b). We also establish that DAG's anticonvulsant mechanism of act
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br Material and methods br Results and discussion br
2021-10-20
Material and methods Results and discussion Discussion It is well established that the guanosine-rich DNA sequences within telomeric DNA repeats, and in the promoter regions of a number of oncogenes or proto-oncogenes such as c-myc [20,23], VEGF [28,48,49] and Bcl-2 [21,50], can readily ass
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Type IIIa b the ligand dependent oncogenic Hh
2021-10-20
Type IIIa/b – the ligand dependent oncogenic Hh pathway (paracrine or reverse paracrine mode) is mediated by paracrine activation and is usually encountered in embryonic development, but also in installation and progression of cancer [58]. Specifically, Hh ligands secreted by malignant myd88 inhibit
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The NF B family of transcription factors is
2021-10-20
The NF-κB family of transcription factors is involved in acquisition of resistance to anticancer drugs as well as to apoptosis. NF-κB-mediated mdr1 gene upregulation is part of the anti-apoptotic protection mechanism of proximal tubule (PT) Meleagrin against cadmium-induced oxidative stress and apo
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