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br Ataxia telangiectasia and Rad related as a therapeutic ta
2023-12-19
Ataxia–telangiectasia and Rad3 related as a therapeutic target Several concerns revolving around functional inhibition of ATR have hindered the exploitation of ATR as therapeutic target in cancer therapy and delayed the development of specific ATR kinase inhibitors. It was anticipated that pharma
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br Apelin Discovered in apelin was initially identified as t
2023-12-19
Apelin Discovered in 1998, apelin was initially identified as the sole endogenous ligand for the APJ receptor (Tatemoto et al., 1998). Apelin-77 (pre-pro-apelin) is the precursor for various pharmacologically active apelin isoforms (e.g. apelin-12, -13, -17 and 36), and it shares 75–95% sequence
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br Results and discussion The soil
2023-12-19
Results and discussion The soil fungus PSU-RSPG37 (BCC56870) was isolated from soil samples collected from Rajjaprabha Dam, Suratthani Province, Thailand. The fungus was deposited at BIOTEC Culture Collection, National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Pa
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br Eprosartan The AT R antagonist eprosartan is approved for
2023-12-19
Eprosartan The AT1R antagonist eprosartan is approved for the treatment of essential Annexin V-Cy3 Apoptosis Kit Plus and may be administered using a convenient once-daily regimen. The drug is a well-tolerated and effective antihypertensive agent with benefit in the secondary prevention of cereb
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br Brain Angiotensin II receptors The information
2023-12-19
Brain Angiotensin II receptors The information above leaves Angiotensin II receptors as the only RAAS components for which localization, regulation of expression and function in the Glutathione (GSH/GSSG/Total) Fluorometric Assay Kit has been convincingly demonstrated, with the use of quantitati
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Women are usually at risk of
2023-12-19
Women are usually at risk of sleep deprivation or restriction during pregnancy, especially in the third trimester of gestation, due to the pregnancy-associated anatomic, physiological and hormonal changes (Pien and Schwab, 2004). However, several major 366 2 developmental events, such as the neurona
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br Acknowledgements br Introduction Diabetic complications
2023-12-19
Acknowledgements Introduction Diabetic complications are responsible for increased morbidity and mortality of diabetic patients. Increased flow of PP242 mg through the polyol pathway under conditions of hyperglycemia contributes to the development of diabetic complications. Aldose reductase (
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We further analyzed selected hit compounds
2023-12-18
We further analyzed selected hit compounds for their ability to inhibit human AdK in intact cells. Human 1321N1 astrocytoma JLK 6 mg were utilized which were found to express AdK. The whole cell assay was performed using a 96-well format. The standard AdK inhibitor 5-iodotubercidin was employed as
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The cytoplasmic domain of muscle
2023-12-18
The cytoplasmic domain of muscle AChR is not accessible to kainate receptors in vivo. Theoretically, therapy with the cytoplasmic domains should be safe. Safety is demonstrated by the facts that: (1) rats repeatedly immunized with the cytoplasmic domains in TiterMax adjuvant do not develop EAMG, al
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br Conflict of interest br Acknowledgements We
2023-12-18
Conflict of interest Acknowledgements We thank Ann Jackman, Mike Ormerod and members of Julian Downward's and Alan Ashworth's groups for helpful discussions. This work was supported by grant number PEM/GME/D391/40 from the Kidani Trust (S. Kaye) and by Keele University. Introduction Autota
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To maintain ATP levels postmortem
2023-12-18
To maintain ATP levels, postmortem muscle mobilizes its glycogen reserves to yield herpes simplex virus 6-phsphate that proceeds through glycolysis. Glycogen degradation was affected by the interaction between treatment and time (Pinitiation of the experiment. We expected that if myosin ATPase is
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br Experimental section br Competing
2023-12-18
Experimental section Competing interests Author's contributions Acknowledgement This research is partially supported by a seed fund for the Center for Drug Discovery and Translational Research (LS) and a research grant by Fujifilm (VPS and LS). The Sponsors played no roles in study desig
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Chromatin proteins play important roles in gene
2023-12-18
Chromatin proteins play important roles in gene expression and DNA repair. The importance of chromatin composition on gene expression is exemplified by X-inactivation, where one of the two X chromosomes in female mammalian Fmoc-Arg(Pbf)-OH is transcriptionally silenced by heterochromatin , , , . In
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Protein phosphorylation is an important posttranslational
2023-12-18
Protein phosphorylation is an important posttranslational mechanism for the regulation of distribution, trafficking, and function of modified proteins (Wang et al., 2014). GluA1 phosphorylation at S845 also has functional consequences (Lu and Roche, 2012). For instance, S845 phosphorylation drove tr
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Although the LB domains of mGlu receptors have not
2023-12-18
Although the LB2 domains of mGlu receptors have not been shown to form an extensive interface during activation, they do draw closer to each other, as demonstrated in crystal structures (Kunishima et al., 2000, Muto et al., 2007, Tsuchiya et al., 2002) and by FRET analysis (Doumazane et al., 2013, V
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