• Pompe disease is accompanied by the deficiency of the lysoso

  2024-11-13

  

  Pompe disease is accompanied by the deficiency of the lysosomal α-1,4-glucosidase that makes the Capsaicin receptor unable to hydrolyze glycogen to glucose, thereby resulting in the accumulation of glycogen in lysosomes, especially in skeletal muscles and cardiac tissues. This accumulation results

• Loss of expression or functional activity of cell adhesion i

  2024-11-13

  

  Loss of expression or functional activity of cell adhesion is intricately related to advanced stages of tumour progression and invasiveness. Martin-Belmonte and Perez-Moreno recently mentioned that the deregulation of adhesion can alter tumourgenesis in the early stage. We have shown for the first t

• br Experimental Procedures br Acknowledgments This work was

  2024-11-13

  

  Experimental Procedures Acknowledgments This work was supported by NIH/National Human Genome Research Institute (NHGRI)R00 HG006922 and NIH/NHGRIR01 HG008974 (to J.G.), the Huntsman Cancer Institute, and the Women’s Cancers Disease-Oriented Team at the Huntsman Cancer Institute. Research repor

• The most likely explanation for the species differences in a

  2024-11-13

  

  The most likely explanation for the species differences in aromatase distribution and the unique C-type natriuretic peptide (1-22) (human, rat, swine) distribution in humans is the unique location, size and highly elaborate organization of the human aromatase gene (e.g. Bulun et al., 2003). The huma

• The current findings proved that citral treatment induced

  2024-11-12

  

  The current findings proved that citral treatment induced mitochondrial-mediated apoptotic cell death in both HCT116 and HT29 through the p53 and ROS. As such, citral promoted apoptosis as evident by the externalization of PS and dissipation of Δψm at 24h of treatment in HCT116 and HT29 cells. These

• CORT induced hippocampal damage has been implicated in depre

  2024-11-12

  

  CORT-induced hippocampal damage has been implicated in depression, aging and long-term glucocorticoid therapy. Therefore, finding a drug that can protect hippocampal neurons from the adverse effects of CORT could have significant clinical benefits. In this regard, we tested the potential protective

• AMI-1 br Material and methods br

  2024-11-12

  

  Material and methods Results Discussion Didox was originally created asa cytostatic drug to inhibit cancer cell proliferation by antagonizing RNR [11]. When used to target highly proliferative cells, Didox has extensive activity in vitro and in vivo. It has also been employed in clinical st

• Although the earlier studies focused on the

  2024-11-12

  

  Although the earlier studies focused on the antioxidant capacity of tocopherols, ascorbic Z-LEHD-FMK synthesis and carotenoids, then it was noticed that phenolic compounds were more powerful than others (Rice-Evans, Miller, & Paganga, 1996). Phenolic compounds, the most numerous and ubiquitous grou

• These experiments make it clear that one can study the

  2024-11-12

  

  These experiments make it clear that one can study the effect of antimalaria drugs that target the DHFR enzyme of P. falciparum by transferring the malaria enzyme into S. cerevisiae. The ease of growth and manipulation of the yeast make it easy to measure the sensitivity of any particular dhfr allel

• br Introduction Increased renin angiotensin

  2024-11-12

  

  Introduction Increased renin-angiotensin system (RAS) activity and inflammation in cardiovascular-related regions of the central nervous system contribute to the overactivity of neurohumoral systems that promote volume retention, cardiac remodeling and serious cardiac arrhythmias in systolic hear

• br AR signals and chemosensitivity in urothelial cancer A si

  2024-11-12

  

  AR signals and chemosensitivity in urothelial cancer A significant amount of patients with urothelial cancer fail to respond to cisplatin-based systemic chemotherapy, although it remains the mainstay of successful management of advanced disease. However, underlying mechanisms for chemoresistance

• Although mature fibrils formed from A aggregates have long

  2024-11-12

  

  Although mature fibrils formed from Aβ e 64 have long been thought to be the main neurodegenerative agents in AD, recent evidence suggests that soluble multimers of these pathogenic proteins, referred to here as “oligomers,” may initiate the synaptic and neuronal dysfunction associated with AD and t

• Not all secondary metabolites or natural

  2024-11-12

  

  Not all secondary metabolites or natural products can be fully synthesized due to their very complex structures that are too difficult and expensive on industrial scale. Hence, there is an urgent need to search for alternative remedies as naturally occurring biologically active secondary metabolites

• It remains to elucidate whether proteolytic activity

  2024-11-12

  

  It remains to elucidate whether proteolytic activity is the cause or the consequence of changing levels of peptidergic substrates. In fact, in some cases, the expression of the enzyme does not necessarily parallel with its activity [26], [55], [57] and other factors such as a definite biochemical en

• One of the specifications of the NIA AA research framework

  2024-11-12

  

  One of the specifications of the NIA-AA research framework was that it glycine transporter be applicable in two distinct research contexts—interventional trials and observational research. In many if not most modern AD interventional trials, individuals are selected for inclusion with the aid of bi

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