• br Material and methods br Results

  2021-07-15

  

  Material and methods Results Discussion Ligase IV is essential for the final ligation of DSBs through the NHEJ pathway. Its co-factor, XRCC4, has been shown to be important for increasing its activity and stability. Interaction between these two factors have been mapped to the linker region

• br Methods To study electrostatic substrate channeling

  2021-07-15

  

  Methods To study electrostatic substrate channeling, we employed two methodologies, Brownian dynamics and a continuum model based on the Smoluchowski theory. Whereas Brownian dynamics simulations are useful for tracking the motion of individual particles, the continuum model is convenient for cal

• In summary in the present study we found that

  2021-07-15

  

  In summary, in the present study we found that CysLT1 receptor attenuates while CysLT2 receptor facilitates OGD-induced PC12 cell death as confirmed by receptor over-expression and antagonism. However, we cannot explain why their roles are distinct and why the cell size is increased in the CysLT2 re

• Oseltamivir phosphate synthesis VHb expression in recombinan

  2021-07-14

  

  VHb expression in recombinant E. coli expressing P4H improved Hyp production, presumably by enhancing oxygen transfer. VHb expression contributed to improving growth and extending the period of exponential growth in both shaker flask culture and bioreactor fermentation. A similar phenomenon was also

• atp citrate lyase The idea of boron based pro estrogens has

  2021-07-14

  

  The idea of boron-based pro-estrogens has been utilized before; in previous studies, the selective estrogen receptor modulators (SERMs) tamoxifen and endoxifen have been masked as boronate esters.13, 14, 15 Tamoxifen and endoxifen both target ERα as therapies for breast cancer. The previous work foc

• Furthermore certain components in the Melanocyte Growth Medi

  2021-07-14

  

  Furthermore, certain components in the Melanocyte Growth Medium seem to influence the response to UV radiation [17]: UV-induced effects on tyrosinase activity were less distinct in melanocytes cultured with phorbol 12-myristate 13-acetate [18], which was also an ingredient in our Melanocyte Growth M

• perhexiline australia Nevertheless because of the preclinica

  2021-07-14

  

  Nevertheless, because of the preclinical work and the interference with EWS–FLI1 transcriptional activity, we believe that there may be a role for ET-743 in Ewing sarcoma. An analysis of the pharmacokinetic data published in the phase II clinical trial shows that at most the drug spent 5 to 6days ou

• The ERR gene lacks the typical TATA and

  2021-07-14

  

  The ERRα gene lacks the typical TATA and CAAT boxes, but has multiple consensus Sp1 binding elements in the GC-rich promoter (Shi et al., 1997). Previously, our laboratory has shown that ERRα expression is upregulated in the mouse uterus by estrogen (Shigeta et al., 1997) and recently we identified

• Fluconazole In summary we have identified a series of

  2021-07-14

  

  In summary, we have identified a series of amides as ERRγ agonists with suitable potency for further development. Our SAR studies of this chemotype identified SR19881 as the most potent full agonist of ERRγ with an EC=0.39 μM in a binding assay and an EC=4.7 μM in a cell-based assay. SR19881 was als

• The underlying assumption of consolidation re

  2021-07-14

  

  The underlying assumption of consolidation/re-consolidation is that the mitotic inhibitors activity initiated during the acquisition trial/re-consolidation trial continues to persist briefly after completion of the trial and it is during this post-trial period that immediate post-trial treatments c

• br O GlcNAc transferase OGT

  2021-07-14

  

  O-GlcNAc transferase OGT belongs to the metal-independent GT-B superfamily of glycosyltransferases, which has been well-reviewed previously [14,15]. OGT is an essential gene encoded on the X-chromosome, and it has two main regions: a long N-terminal tetratricopeptide repeat (TPR) region and a C-t

• Enhanced responses to varying concentrations of bronchoconst

  2021-07-14

  

  Enhanced responses to varying concentrations of bronchoconstrictors, such as MCh, and airway obstruction are characteristic of BI-1356 and common to other clinical states, including chronic obstructive pulmonary disease, lung transplantation, and infection- or chemical agent-induced airway inflamma

• Several main strategies for targeting E s

  2021-07-14

  

  Several main strategies for targeting E3s described in the literature include: in vitro screening using functional assays [86]; computer programs for predicting potential druggable pockets, including those at protein-protein interfaces, and subsequent docking-based in silico ligand screening [87]; f

• Introduction Determining how genes function together as biol

  2021-07-14

  

  Introduction Determining how genes function together as biological systems is a defining challenge of the genomic era. While genome sequences reveal the DNA blueprint of organisms, deciphering how this blueprint leads to biological function is challenging due in large part to the complexity of prot

• br Introduction The ubiquitination status of a

  2021-07-14

  

  Introduction The ubiquitination status of a target protein is achieved via a delicate balance between two opposing forces: ubiquitin E3 ligases and DUBs. It has been postulated that the majority of proteins in a cell are regulated and modified by ubiquitin at some point (Hershko and Ciechanover,

16034 records 636/1069 page Previous Next First page 上5页 636637638639640 下5页 Last page