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Interestingly all three lesions that significantly
2020-05-15
Interestingly, all three lesions that significantly inhibited transcription – CPD, εA and the AP site, – promoted insertion of NS3694 residues opposite the damaged nucleotide. Thus, bacterial RNAP seems to follow the so-called ‘A-rule’ for incorporation of nucleotides opposite AP-sites and bulky les
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br STAR Methods br Acknowledgments We
2020-05-15
STAR★Methods Acknowledgments We are grateful to Matthias Mayer at ZMBH in Heidelberg for access to his CD-spectrometer and his help in data interpretation. Technical support by Wolfgang Weinig is gratefully acknowledged. This project was financially supported by the European Union as part of t
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Apart from neutrophil mediated inflammation the production o
2020-05-15
Apart from neutrophil-mediated inflammation, the production of pro-inflammatory cytokines and chemokines from PGD2/CRTH2 activated macrophages could further aggravate LPS-induced lung injury (Eguchi et al., 2011; Jandl et al., 2016). Interestingly, genetic ablation of CRTH2 diminishes the TNF-α prod
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br Acknowledgements br The oxygenation level has an
2020-05-15
Acknowledgements The oxygenation level has an impact on various aspects of skin physiology, but mechanisms of these effects, including the role of hypoxia in epidermal differentiation, are still poorly understood. The main components of the hypoxia pathway are short-lived transcription factor H
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Since protein kinase CK has over
2020-05-15
Since protein kinase CK2 has over 300 known substrates we examined if the inhibitory effects described above could also be detected using another substrate. Therefore, we employed the synthetic peptide RRRADDSDDDDD which is often used in CK2 inhibitory studies. Quite contrary to the phosphorylation
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Based on the above we hypothesized that a PROTAC strategy
2020-05-15
Based on the above, we hypothesized that a PROTAC strategy would be effective to induce CK2 protein degradation. Herein reported is an approach for the preparation of novel PROTACs via “click reaction” for degradation of CK2 protein (Fig. 2). Importantly, “click reaction” is a very facile, selective
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Simeprevir During mouse embryogenesis RLIM protein is detect
2020-05-15
During mouse embryogenesis, RLIM protein is detectable throughout preimplantation development, consistent with its functions in iXCI maintenance. However, in contrast to differentiating ESCs in culture (Figure 2A), RLIM protein levels are downregulated in nuclei of epiblast cells of implanting embry
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br Genotype phenotype correlations Genotype phenotype
2020-05-14
Genotype-phenotype correlations Genotype-phenotype correlations are limited. Compared with individuals with truncating variants, those with pathogenic missense variants in the adenosine triphosphate binding site had a milder disorder, some with ability to walk unaided, better hand use, and less r
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br Materials and methods br Results
2020-05-14
Materials and methods Results In the leaves of the studied varieties, one to three nucleoli per nucleus were observed (Fig. 1a), except for the variety Bastardo were a maximum of two nucleoli per nucleus were detected. In the root-tip cells, most of the varieties presented one to three nucleo
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Another important issue in biosensors is to design
2020-05-14
Another important issue in biosensors is to design a simple and potable detection strategy to meet the requirement of the point-of-care (POC) test applications. According to the recent research, by using invertase CB-5083 for hydrolyzing sucrose into glucose, the range of personal glucometer has be
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br Introduction The cys loop ligand gated ion
2020-05-14
Introduction The cys-loop ligand gated ion channels (LGICs) are membrane-bound proteins mediating fast transduction from chemical to electrical signals at neuronal synapses and neuromuscular junctions [1], [2]. Each subunit that makes up the pentameric LGIC architecture possesses a dicysteine bri
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br Introduction Breast cancer is the most
2020-05-14
Introduction Breast cancer is the most common malignant tumor in women and the second leading cause of female death [1]. In recent years, with the improvement of early detection and the emergence of new treatment methods, the mortality rate of breast cancer has been greatly reduced. However, the
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The molecular mechanisms regulating the differentiation of T
2020-05-14
The molecular mechanisms regulating the differentiation of Th1 versus Tfh Protease Inhibitor Cocktail (EDTA-Free, 200X in DMSO) from IL-12-stimulated CD4+ T cells remain largely uncharacterized in humans. This topic has been extensively studied in mice (Weinmann, 2014), because IL-12 stimulation pr
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br Ubiquitin Capture by the Mobile
2020-05-14
Ubiquitin Capture by the Mobile APC11 RING Domain Contributes to Processive Substrate Ubiquitylation Although the rules of Ub-mediated proteolysis are only beginning to emerge, the rate and order in which different APC/C substrates are degraded during the indocid correlates with processivity of
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br Conflicts of interest br Introduction G protein
2020-05-14
Conflicts of interest Introduction G protein-coupled receptors (GPCRs), form the largest human membrane protein family, with 800 members overall. Many druggable targets for treatment of common diseases involve GPCRs that mediate therapeutic effects of 34% of all marketed drugs (Hauser, Attwood
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